1-[(3,4,5-Trimethoxyphenyl)methyl]piperazine → HCID 54468974, compound

HRID 2380696Notes

Reaction equation

HRID 2380696 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([CH:15]=[CH:16][CH:17]=2)[CH:10]=[CH:11][C:12]([OH:14])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:30]=[C:31]([O:35][CH3:36])[C:32]=1[O:33][CH3:34])[CH2:23][N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[C:1]1([C:7]2[CH:8]=[C:9]([CH:15]=[CH:16][CH:17]=2)[CH:10]=[CH:11][C:12]([N:27]2[CH2:26][CH2:25][N:24]([CH2:23][C:22]3[CH:30]=[C:31]([O:35][CH3:36])[C:32]([O:33][CH3:34])=[C:20]([O:19][CH3:18])[CH:21]=3)[CH2:29][CH2:28]2)=[O:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 1040951-[(3,4,5-Trimethoxyphenyl)methyl]piperazineHCID 534112783-([1,1'-Biphenyl]-3-yl)acrylic acid

Product 1

HCID 54468974HCID 54468974, compoundYield 85.1%

Procedure

Following a procedure similar to that described in Example 61, but using 0.500 g of 3-phenylcinnamic acid and 0.653 g of 1-(3,4,5-trimethoxybenzyl)piperazine, 0.897 g of the title compound was obtained as a powder.

Sources & evidence

ORD record
ord-05500ed8b5d04323b453e94a9281a672
Source dataset
uspto-grants-1994_11
Patent number
US05369106

Reaction notes

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