HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2380759Generated: October 31, 2026
L-Phenylalanine, methyl ester → HCID 59364047, compound
https://huagongshe.com/reaction/2380759
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | L-Phenylalanine, methyl ester | HCID 736234 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 4-Phenylthiazole-2-carboxylic acid | HCID 3878539 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59364047 | HCID 59364047 | — |
Reaction Steps
To a suspension of 4-Phenyl-thiazole-2-carboxylic acid (100 mg, 0.4 mmol) and 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.44 mmol) in DMF (4 mL) at 25° C. was added phenylalanine methyl ester (72 mg, 0.4 mmol), the resulting mixture was stirring at 25° C. for overnight and concentrated in vacuo, and the residue was dissolved in CH2Cl2 (20 mL) was washed with 5% NaHCO3, dried with MgSO4 and concentrated in vacuo. The residue was purified by HPLC. The product was obtained 92 mg (61%) as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08257931B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-62092a5053954f6fadbf8dce08b598d8 |
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| Source note | uspto-grants-2012_09 |
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