HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylpyruvic acid → HCID 11617017, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylpyruvic acid | HCID 997 | — |
| Reactant | N-methyl-4-phenyl-1,3-thiazol-2-amine | HCID 824443 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 11617017 | HCID 11617017 | 62.1% |
Reaction Steps
To a solution of 2-Oxo-3-phenyl-propionic acid (1.6 mmol, 264 mg) and (4-Phenyl-thiazol-2-yl)-methylamine (1.0 mmol, 190 mg) in MeOH (4 mL), is added NaBH3CN (2.0 mmol, 1N in THF). The pH was then adjusted at 6 with 1M HClaq. The mixture was stirred at room temperature for 3 days. The product was purified by HPLC to give the pure product (210 mg, 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08257931B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-accdf6f97f42477495e66d1febd6ca08 |
| Source note | uspto-grants-2012_09 |