Phosphoric Acid → HCID 86642250, compound

Participants

Reaction Steps

The isolated product of Example 42c can be mixed with tetrahydrofuran, water and LiOH.H2O, and then heated and stirred. The reaction mixture can be later cooled, added with aqueous H3PO4, aqueous NaCl and 2-methyl tetrahydrofuran, and the organic layer is separated, washed and filtered. MeCN is added to the concentrated organic layer, heated and cooled, and then diethylamine is added. The slurry is heated and cooled to form (2R,6S,13aS,14aR,16aS,Z)-6-(2-methylpyrimidine-5-carboxamido)-5,16-dioxo-2-(3-(benzo[d]thiazol-2-yl)quinoxalin-2-yloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylate diethylamine salt, which can be further washed and dried.

Provenance & Evidence