反应详情

To a suspension of 3-amino-5-phenylthiophene-2-carbonitrile (150 mg) in aqueous sodium hydroxide solution (20 mL, 10%) was added ethanol (10 mL) and the mixture was refluxed for 1 h. The reaction mixture was allowed to attain rt and the crystals separated were filtered off, washed with cold water and dried to give the product as a golden yellow color solid (70 mg, 45%), mp 180-182° C.

1. temperaturethe mixture was refluxed for 1 h
2. customto attain rt
3. customthe crystals separated
4. filtrationwere filtered off
5. washwashed with cold water
6. customdried