HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → (S)-1-bromomethyl-2-(3H-imidazol-4-yl)-ethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | HCID 178418337 | HCID 178418337 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-1-bromomethyl-2-(3H-imidazol-4-yl)-ethylamine | HCID 69071454 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
900 mg (S)-histidinol (×2HCl) are dissolved in 20 mL HBr in acetic acid (32%) and heated to 110° C. in the microwave for 6 h. The solvent is eliminated in vacuo, the residue is dissolved in ethanol and again freed from the solvent in vacuo. This crude product is used in the next reaction step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258129B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-f31c1ac2e5a84deb8146f72f9c708390 |
| Source note | uspto-grants-2012_09 |