Formaldehyde → HCID 178461166, compound

HRID 2380819Notes

Reaction equation

HRID 2380819 reaction equation
[N:1]1[CH:5]=[C:4]([CH2:6][C@H:7]([NH2:9])[CH3:8])[NH:3][CH:2]=1.[CH2:10]=O.[OH-].[Na+]>P([O-])([O-])([O-])=O.C(O)C>[CH3:8][C@H:7]1[NH:9][CH2:10][C:5]2[N:1]=[CH:2][NH:3][C:4]=2[CH2:6]1

Participants

6

Reactant 3

HCID 712FormaldehydeHCID 14798Sodium Hydroxide2×HCID 156615alpha-methylhistamine, (R)-

Product 1

HCID 178461166HCID 178461166, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1061PhosphateSolvent

Conditions

Temperature
37 °C

Procedure

0.5 g (R)-2-(3H-imidazol-4-yl)-1-methyl-ethylamine are dissolved in 50 mL phosphate buffer (pH 7) and combined with 1.35 mL formaldehyde. The pH is adjusted to 8 by the addition of 1 N NaOH and the reaction solution is stirred for 12 h at 37° C. Then by the further addition of 1 N NaOH the pH is adjusted to 12, the solvent is eliminated in vacuo, the residue is suspended in ethanol and filtered to remove any undissolved constituents. After elimination of the ethanol in vacuo a crude product is left which is further used directly for the following reactions.

Workup

  1. filtrationfiltered
  2. customto remove any undissolved constituents
  3. waitAfter elimination of the ethanol in vacuo a crude product is left which

Sources & evidence

ORD record
ord-d794a4ca648744829d4ee74781bb4841
Source dataset
uspto-grants-2012_09
Patent number
US08258129B2

Reaction notes

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