HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-trityl-1H-imidazol-4-yl)-propionitrile → 2-(1-trityl-1H-imidazol-4-yl)-propylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-trityl-1H-imidazol-4-yl)-propionitrile | HCID 68872761 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 2-(1-trityl-1H-imidazol-4-yl)-propylamine | HCID 68874852 | — |
Reaction Steps
3.2 g 2-(1-trityl-1H-imidazol-4-yl)-propionitrile are dissolved in 150 mL methanolic ammonia (7 mol/L) and Raney nickel is added. After 12 h and 4 bar H2 pressure the catalyst is filtered off and the solvent is eliminated in vacuo. This crude product is used in the following reaction step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258129B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-58d9ef22ecbd4a9ba3142e4be832db53 |
| Source note | uspto-grants-2012_09 |