Cesium carbonate → HCID 68840504, compound

HRID 2380829Notes

Reaction equation

HRID 2380829 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[O:17]1[CH2:22][CH2:21]O[CH2:19][CH2:18]1>[Pd]>[O:17]1[CH:22]=[CH:21][C:19]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)=[CH:18]1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 114661-Bromo-4-nitrobenzeneHCID 312751,4-Dioxane

Product 1

HCID 68840504HCID 68840504, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

200 mg 4-bromonitrobenzene, 110.8 mg furan-3-boric acid and 162 mg palladium/C are dissolved in 3 mL 1,4-dioxane. Then 965.3 mg caesium carbonate (dissolved in 586 μL water) are added. The reaction is completed in the microwave (110° C.) after 100 min. After aqueous working up the mixture is extracted with ethyl acetate and died on magnesium sulphate. The solvent is eliminated in vacuo. This crude product is used in the following reaction without further purification.

Workup

  1. extractionis extracted with ethyl acetate
  2. customThis crude product is used in the following reaction without further purification

Sources & evidence

ORD record
ord-d8b7f8f9f18545a7855b9817fc73fbac
Source dataset
uspto-grants-2012_09
Patent number
US08258129B2

Reaction notes

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