HCID 68840504, compound → 4-(3-Furanyl)benzenamine

HRID 2380830Notes

Reaction equation

HRID 2380830 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=2)=[CH:2]1>CO.[Pd]>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=2)=[CH:2]1

Participants

4

Reactant 1

HCID 68840504HCID 68840504, compound

Product 1

HCID 444209884-(3-Furanyl)benzenamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

277 mg 4-furan-3-yl-1-nitrobenzene are dissolved in 40 ml of methanol and combined with 200 mg palladium/C. The suspension is shaken at 25° C. for 60 h under a H2 pressure of 5 bar. Then the solvent is eliminated in vacuo. The crude mixture is purified by column chromatography. The carrier material used is silica gel and the mobile phase used is a solvent mixture of cyclohexane/ethyl acetate 50/50. The suitable fractions are freed from the solvent in vacuo.

Workup

  1. customThe crude mixture is purified by column chromatography
  2. additiona solvent mixture of cyclohexane/ethyl acetate 50/50

Sources & evidence

ORD record
ord-81733d53ff544a74b113b0053a06f49e
Source dataset
uspto-grants-2012_09
Patent number
US08258129B2

Reaction notes

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