Hydrochloric Acid → Ethanedioic acid, 1-[2-(4-iodo-2-pyridinyl)hydrazide]

Participants

Reaction Steps

To a solution of ethyl [2-(4-iodopyridin-2-yl)hydrazino](oxo)acetate (0.15 g, 0.41 mmol) in tetrahydrofuran (3.5 mL) was added dropwise a solution of lithium hydroxide (0.030 g, 1.25 mmol) in water (1.5 mL). The resulting mixture was stirred at room temperature for 1 hour. Water was added and it was acidified using hydrochloric acid 2N until pH=3. The formed precipitate was filtered, rinsed with water and dried under vacuum to yield the title compound (0.20 g, 94%) as a white solid.

Provenance & Evidence