Sodium Bicarbonate → HCID 59442955, compound

Participants

Reaction Steps

A solution of the compound obtained in (8) described above (148 mg) in trifluoroacetic acid (2 mL) was stirred at room temperature for an hour. The reaction solution was added dropwise to a saturated aqueous solution of sodium bicarbonate, and the mixture was extracted with chloroform. The organic layer was washed successively with a saturated aqueous solution of sodium bicarbonate and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo. The resultant residue was purified by column chromatography on silica gel (Solvent: n-hexane/ethyl acetate=80/20 to 40/60) to give the titled compound (94 mg) as a pale yellow powder.

Provenance & Evidence