1,4-Dioxane hydrochloride → HCID 59443021, compound

HRID 2380892Notes

Reaction equation

HRID 2380892 reaction equation
[C:1]([C:3]1[C:4]([CH3:29])([CH3:28])[O:5][C:6]2[C:11]([C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)=[CH:10][CH:9]=[C:8]([NH:20]C(=O)OC(C)(C)C)[CH:7]=2)#[N:2].Cl.O1CCOCC1>>[NH2:20][C:8]1[CH:7]=[C:6]2[C:11]([C:12]([C:13]3[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=3)=[C:3]([C:1]#[N:2])[C:4]([CH3:29])([CH3:28])[O:5]2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59443032HCID 59443032, compound

Product 1

HCID 59443021HCID 59443021, compound

Procedure

The compound obtained in (3) described above (250 mg) and 4N hydrochloric acid-dioxane solution (5 mL) were treated in the same manner as Reference Example 5(5) to give the titled compound (148 mg) as a yellow powder.

Sources & evidence

ORD record
ord-167cf659e14146b18ec3a675e2d3e7ec
Source dataset
uspto-grants-2012_09
Patent number
US08258131B2

Reaction notes

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