1,4-Dioxane hydrochloride → [3-cyclopropyl-4-(4-fluorophenyl)-2,2-dimethyl-2H-chromen-7-yl]amine

HRID 2380896Notes

Reaction equation

HRID 2380896 reaction equation
[CH:1]1([C:4]2[C:5]([CH3:30])([CH3:29])[O:6][C:7]3[C:12]([C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[CH:11][CH:10]=[C:9]([NH:21]C(=O)OC(C)(C)C)[CH:8]=3)[CH2:3][CH2:2]1.Cl.O1CCOCC1>>[CH:1]1([C:4]2[C:5]([CH3:30])([CH3:29])[O:6][C:7]3[C:12]([C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[CH:11][CH:10]=[C:9]([NH2:21])[CH:8]=3)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59443016tert-butyl [3-cyclopropyl-4-(4-fluorophenyl)-2,2-dimethyl-2H-chromen-7-yl]carbamate

Product 1

HCID 59442974[3-cyclopropyl-4-(4-fluorophenyl)-2,2-dimethyl-2H-chromen-7-yl]amine

Procedure

The compound obtained in (2) described above (115 mg) and 4N hydrochloric acid-dioxane solution (4 mL) were treated in the same manner as Reference Example 5(5) to give the titled compound as a crude product (a yellow powder).

Sources & evidence

ORD record
ord-e5b5c501739b46c5a64fc9acc9e65bf9
Source dataset
uspto-grants-2012_09
Patent number
US08258131B2

Reaction notes

Loading…