tert-Butyl carbamate → tert-butyl [4-(4-fluorophenyl)-2,2-dimethyl-3-vinyl-2H-chromen-7-yl]carbamate

HRID 2380898Notes

Reaction equation

HRID 2380898 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)=[C:7]([CH:14]=[CH2:15])[C:8]([CH3:13])([CH3:12])[O:9]2)=[CH:4][CH:3]=1.[C:23](=[O:30])([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])[NH2:24]>>[F:22][C:19]1[CH:20]=[CH:21][C:16]([C:6]2[C:5]3[C:10](=[CH:11][C:2]([NH:24][C:23](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[CH:3][CH:4]=3)[O:9][C:8]([CH3:13])([CH3:12])[C:7]=2[CH:14]=[CH2:15])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 594429667-chloro-4-(4-fluorophenyl)-2,2-dimethyl-3-vinyl-2H-chromen

Product 1

HCID 59442986tert-butyl [4-(4-fluorophenyl)-2,2-dimethyl-3-vinyl-2H-chromen-7-yl]carbamate

Procedure

The compound obtained in (1) described above (155 mg) and tert-butyl carbamate (280 mg) were treated in the same manner as Reference Example 5(4) to give the titled compound (185 mg) as a yellow powder.

Sources & evidence

ORD record
ord-b07e1bcaa5a041809d09e2eea3db89af
Source dataset
uspto-grants-2012_09
Patent number
US08258131B2

Reaction notes

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