反应详情

The compound obtained in (1) described above (140 mg) and 4N hydrochloric acid-dioxane solution (5 mL) were stirred at room temperature for 2 hours. The reaction solution was concentrated in vacuo, and to the resultant residue was added a saturated aqueous solution of sodium bicarbonate, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, filtered through a column of porous diatomite (Chem Elut) and the filtrate was concentrated in vacuo. The resultant residue was purified by column chromatography on silica gel (Solvent: n-hexane/ethyl acetate=98/2 to 90/10) to give the titled compound (121 mg) as a pale yellow powder.

1. concentrationThe reaction solution was concentrated in vacuo
2. additionto the resultant residue was added a saturated aqueous solution of sodium bicarbonate
3. extractionthe mixture was extracted with ethyl acetate
4. washThe organic layer was washed with brine
5. filtrationfiltered through a column of porous diatomite (Chem Elut)
6. concentrationthe filtrate was concentrated in vacuo
7. customThe resultant residue was purified by column chromatography on silica gel (Solvent: n-hexane/ethyl acetate=98/2 to 90/10)