Cesium carbonate → HCID 59442920, compound

Participants

Reaction Steps

A mixture of the compound obtained in (3) described above (3.5 g), 4-fluorophenylboronic acid (1 g), cesium carbonate (12.7 g) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (350 mg, 10% wt) in dimethoxyethane/water (3/1; 60 mL) was heated under reflux under nitrogen atmosphere for 12 hours. The reaction solution was concentrated in vacuo, and the residue was extracted with ethyl acetate (40 ml×3). The combined organic layer was washed with saturated brine, dried over sodium sulfate, filtered and the filtrate was concentrated in vacuo. The residue is purified by column chromatography on silica gel (Solvent: petroleum ether/ethyl acetate=20/1) to give the titled compound (2 g) as a colorless powder.

Provenance & Evidence