Ethyl Acetate → HCID 59443042, compound

Participants

Reaction Steps

A mixture of the compound obtained in (1) described above (1.75 g), 4-fluorophenylboronic acid (1.53 g), potassium carbonate (1.55 g) and a catalytic amount of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) in dimethoxyethane (30 mL) was heated under reflux under nitrogen atmosphere overnight. After cooling to room temperature, to the reaction mixture was added ethyl acetate (30 mL) and saturated brine (30 mL). The organic layer was separated and washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue is purified by flush chromatography on silica gel (petroleum ether/ethyl acetate=10/0 to 10/1) to give the titled compound (1.0 g) as a yellow powder.

Provenance & Evidence