Triethylamine → HCID 46181767, compound

Participants

Reaction Steps

To a stirred solution of 4-[benzyl-(1-methyl-1H-imidazole-4-sulfonyl)-amino]-benzoic acid (37 mg, 0.1 mmol) in dry dimethylformamide (1 ml) was added N-methylpiperazine (20 mg, 0.2 mmol), triethylamine (28 μl, 0.2 mmol) then 2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (42 mg, 0.11 mmol) and the solution was stirred at room temperature for 16 hours. The reaction mixture was concentrated in vacuo and the residue purified using preparative HPLC to afford the title compound as a clear oil (30 mg, 66% HPLC retention time 4.5 min. Mass spectrum (ES+) m/z 454 (M+H).

Provenance & Evidence