Methyl iodide → (2-Chloro-quinazolin-4-yl)-(3-methoxy-phenyl)-methyl-amine

HRID 2380987Notes

Reaction equation

HRID 2380987 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:21]I>>[Cl:1][C:2]1[N:11]=[C:10]([N:12]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=2)[CH3:21])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 22692724HCID 22692724, compound

Product 1

HCID 11277975(2-Chloro-quinazolin-4-yl)-(3-methoxy-phenyl)-methyl-amine

Procedure

The title compound was prepared from (2-chloro-quinazolin-4-yl)-(3-methoxy-phenyl)-amine and methyl iodide by a procedure similar to example 7 (60% yield). 1H NMR (CDCl3): 7.74-7.76 (m, 1H), 7.57 (ddd, J=8.4, 6.0 and 1.8 Hz, 1H), 7.32 (t, J=7.8 Hz, 1H), 6.98-7.03 (m, 2H), 6.89 (dd, J=8.1 and 2.4 Hz, 1H), 6.75-6.81 (m, 2H), 3.65 (s, 3H), 3.37 (s, 3H).

Sources & evidence

ORD record
ord-a8690af562fc4881af2345d63561cf0a
Source dataset
uspto-grants-2012_09
Patent number
US08258145B2

Reaction notes

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