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Methyl iodide → (2-Chloro-quinazolin-4-yl)-(2,3-dimethoxy-phenyl)-methyl-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | 2-Chloro-N-(2,3-dimethoxyphenyl)quinazolin-4-amine | HCID 57938809 | — |
| 生成物 | (2-Chloro-quinazolin-4-yl)-(2,3-dimethoxy-phenyl)-methyl-amine | HCID 11244386 | — |
反応手順
The title compound was prepared from (2-chloro-quinazolin-4-yl)-(2,3-dimethoxy-phenyl)-amine and methyl iodide by a procedure similar to Example 7 (71% yield). 1H NMR (CDCl3): 7.74 (d, J=8.4 Hz, 1H), 7.53-7.59 (m, 1H), 7.12 (t, J=8.4 Hz, 1H), 6.94-7.01 (m, 3H), 6.87 (dd, J=8.1 and 1.5 Hz, 1H), 3.89 (s, 3H), 3.56 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08258145B2 |
| 出典データセット | uspto-grants-2012_09 |
| ORD ID | ord-da8dc789ef7a444082e4da846012119e |
| 出典メモ | uspto-grants-2012_09 |