HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 4-Quinazolinamine, N-(3-fluoro-4-methoxyphenyl)-N,2-dimethyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | N-(3-Fluoro-4-methoxyphenyl)-2-methylquinazolin-4-amine | HCID 42625836 | — |
| Product | 4-Quinazolinamine, N-(3-fluoro-4-methoxyphenyl)-N,2-dimethyl- | HCID 11460696 | — |
Reaction Steps
The title compound was prepared from (3-fluoro-4-methoxy-phenyl)-(2-methyl-quinazolin-4-yl)-amine (250 mg, 0.88 mmol) and methyl iodide (0.39 ml, 6.18 mmol) by a procedure similar to example 7. 1H NMR (CDCl3): 7.76 (d, J=8.4 Hz, 1H), 7.59-7.53 (m, 1H), 7.09-6.82 (m, 5H), 3.91 (s, 3H), 3.58 (s, 3H), 2.73 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258145B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-4aca2f2784e546eeb8cb2e45b86ae761 |
| Source note | uspto-grants-2012_09 |