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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2380998Generated: November 2, 2026

Methyl iodide → 4-Quinazolinamine, N-(3-fluoro-4-methoxyphenyl)-N,2-dimethyl-

https://huagongshe.com/reaction/2380998

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
ReactantN-(3-Fluoro-4-methoxyphenyl)-2-methylquinazolin-4-amineHCID 42625836—
Product4-Quinazolinamine, N-(3-fluoro-4-methoxyphenyl)-N,2-dimethyl-HCID 11460696—

Reaction Steps

The title compound was prepared from (3-fluoro-4-methoxy-phenyl)-(2-methyl-quinazolin-4-yl)-amine (250 mg, 0.88 mmol) and methyl iodide (0.39 ml, 6.18 mmol) by a procedure similar to example 7. 1H NMR (CDCl3): 7.76 (d, J=8.4 Hz, 1H), 7.59-7.53 (m, 1H), 7.09-6.82 (m, 5H), 3.91 (s, 3H), 3.58 (s, 3H), 2.73 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08258145B2
Source datasetuspto-grants-2012_09
ORD IDord-4aca2f2784e546eeb8cb2e45b86ae761
Source noteuspto-grants-2012_09