Heptane → HCID 11102070, compound

Temperature

30 °C

To 350 mL of heptane, 70.0 g (156 mmol) of 4-acetoxy-3,5-di-tert-butyl-2-(1-hydroxy-2-pentylheptyl)phenol was added and the mixture was cooled to 10° C. or below. To the mixture, 44.3 g (312 mmol) of a boron trifluoride/diethyl ether complex was added dropwise at 10° C. or below and the mixture was warmed to 30° C. and stirred for 5.5 hours. The solution was cooled to 10° C. or below and thereafter, 350 mL of 7.5% aqueous sodium hydrogencarbonate was added, followed by stirring. The mixture was subjected to liquid-liquid separation and the organic layer was washed with 280 mL of water; thereafter, 7.8 g (40.4 mmol) of 28% sodium methylate and 28 mL of methanol were added and the mixture was stirred for 0.5 hours at room temperature. To the reaction mixture, 280 mL of water was added, followed by stirring; the aqueous layer was discarded and the organic layer was washed with 280 mL of water. To the organic layer, 28.0 g of anhydrous magnesium sulfate and 70.0 g of activated alumina were sequentially added and the mixture was stirred for 0.5 hours at room temperature. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure; thereafter, 70 mL of 1-propanol was added and the mixture was again concentrated under reduced pressure. To the residue, 70 mL of 1-propanol was added to give a solution of 5-acetoxy-4,6-di-tert-butyl-2,2-dipentyl-2,3-dihydrobenzofuran in 1-propanol.

1. temperaturethe mixture was cooled to 10° C. or below
2. additionTo the mixture, 44.3 g (312 mmol) of a boron trifluoride/diethyl ether complex was added dropwise at 10° C. or below
3. temperatureThe solution was cooled to 10° C. or below
4. stirringby stirring
5. customThe mixture was subjected to liquid-liquid separation
6. washthe organic layer was washed with 280 mL of water
7. stirringthe mixture was stirred for 0.5 hours at room temperature
8. stirringby stirring
9. washthe organic layer was washed with 280 mL of water
10. additionTo the organic layer, 28.0 g of anhydrous magnesium sulfate and 70.0 g of activated alumina were sequentially added
11. stirringthe mixture was stirred for 0.5 hours at room temperature
12. filtrationThe reaction mixture was filtered
13. concentrationthe filtrate was concentrated under reduced pressure
14. additionthereafter, 70 mL of 1-propanol was added
15. concentrationthe mixture was again concentrated under reduced pressure
16. additionTo the residue, 70 mL of 1-propanol was added

ORD record

ord-165f1bc97c9a4e6c99e2cf35c2063a43

Source dataset

uspto-grants-2005_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06852867B2