HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 11500994, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Methyl-N-(3,4,5-trimethoxyphenyl)quinazolin-4-amine | HCID 59648369 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 11500994 | HCID 11500994 | — |
Reaction Steps
The title compound was prepared from (3,4,5-trimethoxy-phenyl)-(2-methyl-quinazolin-4-yl)-amine (232 mg, 0.71 mmol), methyl iodide (0.07 ml, 1.08 mmol), sodium hydride (43 mg, 1.08 mmol, 60% oil dispersion) in DMF similar to example 49 to give 65 mg (27%) of white solids. 1H NMR (CDCl3): 7.75 (d, J=8.4 Hz, 1H), 7.58-7.53 (m, 1H), 7.11-7.00 (m, 2H), 6.39 (s, 2H), 3.88 (s, 3H), 3.73 (s, 6H), 3.62 (s, 3H), 2.74 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258145B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-da76fa741ddd477ab088ddd53c351831 |
| Source note | uspto-grants-2012_09 |