Hydrochloric Acid → HCID 86643600, compound

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To a solution of (S)-3-(4-Benzyloxy-3-methylcarbamoyloxy-phenyl)-2-tert-butoxy-carbonylamino-propionic acid methyl ester (0.80 g) in dichloromethane (10 ml) was added HCl solution (4M in dioxane, 4 ml) at 0° C. The mixture was stirred at this temperature for 2 h. Diethyl ether was added and a white solid precipitated. (S)-2-(4-Benzyloxy-3-methylcarbamoyloxy-phenyl)-1-methoxycarbonyl-ethyl-ammonium chloride was obtained by filtration as a white solid, 0.654 g. 1H NMR (400 MHz, d6-DMSO) 2.65 (d, 3H), 3.01-3.14 (m, 2H), 3.67 (s, 3H), 4.24 (m, 1H), 5.10 (s, 2H), 7.01-7.11 (m, 3H), 7.30-7.44 (m, 5H), 7.61 (m, 1H), 8.64 (br, 3H).

Provenance & Evidence