Diethyl Ether → HCID 86643604, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-3-(3-benzyloxy-4-methylcarbamoyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester (0.90 g) in dichloromethane (12 ml) cooled with an ice-bath was added 4 MHCl in dioxane (6 ml). The mixture was stirred at 0° C. for 2 h. Diethyl ether was added and a white solid was precipitated. (S)-2-(3-Benzyloxy-4-methylcarbamoyloxy-phenyl)-1-methoxycarbonyl-ethyl-ammonium chloride was obtained as white solid by filtration, 0.83 g. 1H NMR (400 MHz, d6-DMSO) 2.64 (s, 3H), 3.10 (m, 2H), 3.68 (s, 3H), 4.33 (m, 1H), 5.10 (s, 2H), 6.79 (m, 1H), 7.04-7.12 (m, 2H), 7.32-7.45 (m, 5H), 7.60 (m, 1H), 8.64 (s, 3H).

Provenance & Evidence