関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Propylphosphonic anhydride | HCID 111923 | — |
| 反応物 | N-(2,6-Dimethylphenyl)formamide | HCID 345859 | — |
| 反応物 | 2-Amino-5-fluoropyridine | HCID 2737701 | — |
| 反応物 | Propylphosphoric anhydride | HCID 16167369 | — |
| 反応物 | 2-(2-Formyl-3-methoxyphenoxy)acetamide | HCID 42604614 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | HCID 24854988 | HCID 24854988 | — |
反応手順
4.2 0.149 g of 12, 0.112 g of 2-amino-5-fluoropyridine 4, 0.209 g of 2-(2-formyl-3-methoxyphenoxy)acetamide 3, 0.286 ml of triethylamine and, dropwise, 2.5 ml of T3P® [=propylphosphonic anhydride (50% solution in ethyl acetate)] are introduced successively into a flask with ice-cooling and under an inert gas. The reaction mixture is stirred at 100° C. for 7 h. The mixture is subsequently subjected to conventional work-up, giving 0.2 g (40%) of “A1”.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08258151B2 |
|---|
| 出典データセット | uspto-grants-2012_09 |
|---|
| ORD ID | ord-df4dd51a7ae14f998fd7e0c33560e0bc |
|---|
| 出典メモ | uspto-grants-2012_09 |
|---|
