1H-Pyrrolo(2,3-b)pyridine → HCID 59542847, compound

HRID 2381113Notes

Reaction equation

HRID 2381113 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[N:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]3)[CH2:10][CH2:11][C:6]2=[N:5][N:4]=1.[NH:21]1[C:25]2=[N:26][CH:27]=[CH:28][CH:29]=[C:24]2[CH:23]=[CH:22]1>>[NH:21]1[C:25]2=[N:26][CH:27]=[CH:28][CH:29]=[C:24]2[C:23]([C:15]2[CH2:14][CH2:13][N:12]([C:9]3[CH2:10][CH2:11][C:6]4[N:7]([C:3]([C:2]([F:20])([F:19])[F:1])=[N:4][N:5]=4)[N:8]=3)[CH2:17][CH:16]=2)=[CH:22]1

Participants

3

Reactant 2

HCID 92221H-Pyrrolo(2,3-b)pyridineHCID 68502134HCID 68502134, compound

Product 1

HCID 59542847HCID 59542847, compoundYield 27%

Procedure

Obtained in 27% yield by an analogous method to Example 2, starting from 1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-one and 1H-pyrrolo[2,3-b]pyridine.

Workup

  1. customObtained in 27% yield by an analogous method to Example 2

Sources & evidence

ORD record
ord-debcdcab86ce43dc94919db33aa5f6d6
Source dataset
uspto-grants-2012_09
Patent number
US08258140B2

Reaction notes

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