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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2381118Generated: November 2, 2026

Methyl 4-bromobutyrate → Methyl 4-[4-[1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]butanoate

https://huagongshe.com/reaction/2381118

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-bromobutyrateHCID 107604—
Reactant4-(1-(3-(Trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenolHCID 36730078—
ProductMethyl 4-[4-[1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]butanoateHCID 6850387763%

Reaction Steps

Obtained in 63% yield by an analogous method to Example 19, preparation of starting materials, starting from 4-[1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenol and methyl 4-bromobutanoate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08258140B2
Source datasetuspto-grants-2012_09
ORD IDord-c6c88c25361b4245ace9c8b7392c87be
Source noteuspto-grants-2012_09