(2-Methoxyethyl)(methyl)amine → HCID 68498003, compound

HRID 2381119Notes

Reaction equation

HRID 2381119 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[N:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][CH:15]([C:18]4[CH:30]=[CH:29][C:21]([O:22][CH2:23][CH2:24][CH2:25][C:26](O)=[O:27])=[CH:20][CH:19]=4)[CH2:14][CH2:13]3)[CH:10]=[CH:11][C:6]2=[N:5][N:4]=1.[CH3:33][O:34][CH2:35][CH2:36][NH:37][CH3:38]>>[CH3:33][O:34][CH2:35][CH2:36][N:37]([CH3:38])[C:26](=[O:27])[CH2:25][CH2:24][CH2:23][O:22][C:21]1[CH:20]=[CH:19][C:18]([CH:15]2[CH2:16][CH2:17][N:12]([C:9]3[CH:10]=[CH:11][C:6]4[N:7]([C:3]([C:2]([F:31])([F:1])[F:32])=[N:4][N:5]=4)[N:8]=3)[CH2:13][CH2:14]2)=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 300977(2-Methoxyethyl)(methyl)amineHCID 68502145HCID 68502145, compound

Product 1

HCID 68498003HCID 68498003, compoundYield 50%

Procedure

Obtained in 50% yield by an analogous method to Example 19, starting from 4-[4-[1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]butanoic acid and N-(2-methoxyethyl)methylamine.

Workup

  1. customObtained in 50% yield by an analogous method to Example 19

Sources & evidence

ORD record
ord-83c9aca0c1bb4e20ac65530b7389c694
Source dataset
uspto-grants-2012_09
Patent number
US08258140B2

Reaction notes

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