HRID2381125

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7991

Pentanoic acid

C5H10O2

结构：CC(=O)N1CCN(CCCOc2ccc(N3CCN(C4=Nn5c(nnc5C(F)(F)F)CC4)CC3)cc2)CC1

HCID59542850

未命名化合物

PRODUCTS

生成物

结构：CCCCC(=O)N1CCN(CCCOc2ccc(N3CCN(C4=Nn5c(nnc5C(F)(F)F)CC4)CC3)cc2)CC1

HCID46892045

未命名化合物

收率 70%

PROCEDURE

实验过程

Obtained in 70% yield by an analogous method to Example 4.1, starting from 6-{4-[4-(3-piperazin-1-ylpropoxy)phenyl]piperazin-1-yl}-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine (obtained as described in Example 29, preparation of starting materials) and pentanoic acid.

WORKUP

后处理

customObtained in 70% yield by an analogous method to Example 4.1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-234eac945a144c0abe761272ce158849
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08258140B2
来源说明: uspto-grants-2012_09

反应 SMILES

[C:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][N:23]([C:26]4[CH2:27][CH2:28][C:29]5[N:30]([C:32]([C:35]([F:38])([F:37])[F:36])=[N:33][N:34]=5)[N:31]=4)[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[C:39](O)(=O)[CH2:40][CH2:41]CC>>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:15]=[CH:16][C:17]([N:20]3[CH2:25][CH2:24][N:23]([C:26]4[CH2:27][CH2:28][C:29]5[N:30]([C:32]([C:35]([F:37])([F:36])[F:38])=[N:33][N:34]=5)[N:31]=4)[CH2:22][CH2:21]3)=[CH:18][CH:19]=2)[CH2:6][CH2:5]1)(=[O:3])[CH2:2][CH2:39][CH2:40][CH3:41]