Pentanoic Acid → HCID 46892045, compound

HRID 2381125Notes

Reaction equation

HRID 2381125 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][N:23]([C:26]4[CH2:27][CH2:28][C:29]5[N:30]([C:32]([C:35]([F:38])([F:37])[F:36])=[N:33][N:34]=5)[N:31]=4)[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[C:39](O)(=O)[CH2:40][CH2:41]CC>>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:15]=[CH:16][C:17]([N:20]3[CH2:25][CH2:24][N:23]([C:26]4[CH2:27][CH2:28][C:29]5[N:30]([C:32]([C:35]([F:37])([F:36])[F:38])=[N:33][N:34]=5)[N:31]=4)[CH2:22][CH2:21]3)=[CH:18][CH:19]=2)[CH2:6][CH2:5]1)(=[O:3])[CH2:2][CH2:39][CH2:40][CH3:41]

Participants

3

Reactant 2

HCID 7991Pentanoic AcidHCID 59542850HCID 59542850, compound

Product 1

HCID 46892045HCID 46892045, compoundYield 70%

Procedure

Obtained in 70% yield by an analogous method to Example 4.1, starting from 6-{4-[4-(3-piperazin-1-ylpropoxy)phenyl]piperazin-1-yl}-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine (obtained as described in Example 29, preparation of starting materials) and pentanoic acid.

Workup

  1. customObtained in 70% yield by an analogous method to Example 4.1

Sources & evidence

ORD record
ord-234eac945a144c0abe761272ce158849
Source dataset
uspto-grants-2012_09
Patent number
US08258140B2

Reaction notes

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