Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate → HCID 68501637, compound

HRID 2381126Notes

Reaction equation

HRID 2381126 reaction equation
CN1C([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][N:19]([C:22]4[CH2:23][CH2:24][C:25]5[N:26]([C:28]([C:31]([F:34])([F:33])[F:32])=[N:29][N:30]=5)[N:27]=4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)=CC=N1.OCC[N:38]1[CH2:43][CH2:42][N:41]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:40][CH2:39]1>>[F:34][C:31]([F:32])([F:33])[C:28]1[N:26]2[N:27]=[C:22]([N:19]3[CH2:18][CH2:17][N:16]([C:13]4[CH:14]=[CH:15][C:10]([O:9][CH2:8][CH2:7][N:38]5[CH2:39][CH2:40][N:41]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:42][CH2:43]5)=[CH:11][CH:12]=4)[CH2:21][CH2:20]3)[CH:23]=[CH:24][C:25]2=[N:30][N:29]=1

Participants

3

Reactant 2

HCID 735736Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylateHCID 46893851HCID 46893851, compound

Product 1

HCID 68501637HCID 68501637, compoundYield 60%

Procedure

Obtained in 60% yield by an analogous method to Example 29, preparation of starting materials, starting from 4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}phenol (obtained as described in Example 16, preparation of starting materials) and tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (CAS 77279-24-4).

Workup

  1. customObtained in 60% yield by an analogous method to Example 29, preparation of starting materials

Sources & evidence

ORD record
ord-32983f19790c430a9593db90e58fb3d4
Source dataset
uspto-grants-2012_09
Patent number
US08258140B2

Reaction notes

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