HRID2381127

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7991

Pentanoic acid

C5H10O2

结构：CC(=O)N1CCN(CCOc2ccc(N3CCN(C4=Nn5c(nnc5C(F)(F)F)CC4)CC3)cc2)CC1

HCID46892047

未命名化合物

PRODUCTS

生成物

结构：CCCCC(=O)N1CCN(CCOc2ccc(N3CCN(C4=Nn5c(nnc5C(F)(F)F)CC4)CC3)cc2)CC1

HCID46892178

未命名化合物

收率 77%

PROCEDURE

实验过程

Obtained in 77% yield by an analogous method to Example 4.1, starting from 6-[4-[4-[2-(piperazin-1-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazine (obtained as described in Example 32, preparation of starting materials) and pentanoic acid.

WORKUP

后处理

customObtained in 77% yield by an analogous method to Example 4.1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d2063cf4dcf049f1807d8e694d77b8ef
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08258140B2
来源说明: uspto-grants-2012_09

反应 SMILES

[C:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:24][CH2:23][N:22]([C:25]4[CH2:26][CH2:27][C:28]5[N:29]([C:31]([C:34]([F:37])([F:36])[F:35])=[N:32][N:33]=5)[N:30]=4)[CH2:21][CH2:20]3)=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[C:38](O)(=O)[CH2:39][CH2:40]CC>>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([CH2:10][CH2:11][O:12][C:13]2[CH:14]=[CH:15][C:16]([N:19]3[CH2:24][CH2:23][N:22]([C:25]4[CH2:26][CH2:27][C:28]5[N:29]([C:31]([C:34]([F:36])([F:35])[F:37])=[N:32][N:33]=5)[N:30]=4)[CH2:21][CH2:20]3)=[CH:17][CH:18]=2)[CH2:8][CH2:9]1)(=[O:3])[CH2:2][CH2:38][CH2:39][CH3:40]