Pentanoic Acid → HCID 46892178, compound

HRID 2381127Notes

Reaction equation

HRID 2381127 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:24][CH2:23][N:22]([C:25]4[CH2:26][CH2:27][C:28]5[N:29]([C:31]([C:34]([F:37])([F:36])[F:35])=[N:32][N:33]=5)[N:30]=4)[CH2:21][CH2:20]3)=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[C:38](O)(=O)[CH2:39][CH2:40]CC>>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([CH2:10][CH2:11][O:12][C:13]2[CH:14]=[CH:15][C:16]([N:19]3[CH2:24][CH2:23][N:22]([C:25]4[CH2:26][CH2:27][C:28]5[N:29]([C:31]([C:34]([F:36])([F:35])[F:37])=[N:32][N:33]=5)[N:30]=4)[CH2:21][CH2:20]3)=[CH:17][CH:18]=2)[CH2:8][CH2:9]1)(=[O:3])[CH2:2][CH2:38][CH2:39][CH3:40]

Participants

3

Reactant 2

HCID 7991Pentanoic AcidHCID 46892047HCID 46892047, compound

Product 1

HCID 46892178HCID 46892178, compoundYield 77%

Procedure

Obtained in 77% yield by an analogous method to Example 4.1, starting from 6-[4-[4-[2-(piperazin-1-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazine (obtained as described in Example 32, preparation of starting materials) and pentanoic acid.

Workup

  1. customObtained in 77% yield by an analogous method to Example 4.1

Sources & evidence

ORD record
ord-d2063cf4dcf049f1807d8e694d77b8ef
Source dataset
uspto-grants-2012_09
Patent number
US08258140B2

Reaction notes

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