Methanesulfonyl chloride → HCID 46892179, compound

HRID 2381128Notes

Reaction equation

C([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:24][CH2:23][N:22]([C:25]4[CH2:26][CH2:27][C:28]5[N:29]([C:31]([C:34]([F:37])([F:36])[F:35])=[N:32][N:33]=5)[N:30]=4)[CH2:21][CH2:20]3)=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=O)C.[CH3:38][S:39](Cl)(=[O:41])=[O:40]>>[CH3:38][S:39]([N:4]1[CH2:5][CH2:6][N:7]([CH2:10][CH2:11][O:12][C:13]2[CH:14]=[CH:15][C:16]([N:19]3[CH2:20][CH2:21][N:22]([C:25]4[CH2:26][CH2:27][C:28]5[N:29]([C:31]([C:34]([F:35])([F:36])[F:37])=[N:32][N:33]=5)[N:30]=4)[CH2:23][CH2:24]3)=[CH:17][CH:18]=2)[CH2:8][CH2:9]1)(=[O:41])=[O:40]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 46892047HCID 46892047, compound

Product 1

HCID 46892179HCID 46892179, compoundYield 75%

Procedure

Obtained in 75% yield by an analogous method to Example 26, starting from 6-[4-[4-[2-(piperazin-1-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazine (obtained as described in Example 32, preparation of starting materials) and methanesulfonyl chloride.

Workup

customObtained in 75% yield by an analogous method to Example 26

Sources & evidence

ORD record: ord-d8f18196e7e34ee79d02f31c8248cb0e
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08258140B2

Reaction notes

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