HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Benzyloxy-4-(4-bromo-2,6-difluoroanilino)-6-methoxyquinazoline → 4-(4-Bromo-2,6-difluoroanilino)-7-hydroxy-6-methoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Benzyloxy-4-(4-bromo-2,6-difluoroanilino)-6-methoxyquinazoline | HCID 10790605 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 4-(4-Bromo-2,6-difluoroanilino)-7-hydroxy-6-methoxyquinazoline | HCID 135493544 | 98% |
Reaction Steps
Using an analogous procedure to that described for the synthesis of the starting material in Example 8, 7-benzyloxy-4-(4-bromo-2,6-difluoroanilino)-6-methoxyquinazoline (1.9 g, 4.02 mmol) was reacted with TFA (20 ml) to give 4-(4-bromo-2,6-difluoroanilino)-7-hydroxy-6-methoxyquinazoline (1.5 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642608B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-af756cdcaeec46bf8af0d22612aa3663 |
| Source note | uspto-grants-2014_02 |