反应详情

Obtained in 41% yield by an analogous method to Example 51, starting from 4-{1-[3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenol and (S)-2-(4-acetyl-3-methylpiperazin-1-yl)ethanol (obtained by an analogous method to the R enantiomer as described in Example 51, preparation of starting materials).

1. customObtained in 41% yield by an analogous method to Example 51
2. customobtained by an analogous method to the R enantiomer
3. customas described in Example 51, preparation of starting materials)