Trifluoroacetic acid → N-(4-chloro-2,6-difluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	7-(1-(Tert-butoxycarbonyl)piperidin-4-ylmethoxy)-4-(4-chloro-2,6-difluoroanilino)-6-methoxyquinazoline	HCID 11135280	—
Solvent	Dichloromethane	HCID 6344	—
Product	N-(4-chloro-2,6-difluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine	HCID 5329050	26%

Reaction Steps

Using an analogous procedure to that described in Example 9, 7-(1-(tert-butoxycarbonyl)piperidin-4-ylmethoxy)-4-(4-chloro-2,6-difluoroanilino)-6-methoxyquinazoline (95 mg, 0.2 mmol) in methylene chloride (2 ml) was treated with TFA (800 μl) to give 4-(4-chloro-2,6-difluoroanilino)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazoline (20 mg, 26%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08642608B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-2849ae95f51042f38bc9760be739b146
Source note	uspto-grants-2014_02