3-Cyclopropylpropanoic acid → 1-(3-Cyclopropyl-propionyl)-piperidine-4-carboxylic acid (4-isopropyl-phenyl)-amide

HRID 2381166Notes

Reaction equation

HRID 2381166 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[O:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH:19]1([CH2:22][CH2:23][C:24](O)=[O:25])[CH2:21][CH2:20]1>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11]([CH:13]2[CH2:18][CH2:17][N:16]([C:24](=[O:25])[CH2:23][CH2:22][CH:19]3[CH2:21][CH2:20]3)[CH2:15][CH2:14]2)=[O:12])=[CH:8][CH:9]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27580133-Cyclopropylpropanoic acidHCID 18071890Piperidine-4-carboxylic acid (4-isopropyl-phenyl)-amide

Product 1

HCID 510009131-(3-Cyclopropyl-propionyl)-piperidine-4-carboxylic acid (4-isopropyl-phenyl)-amide

Procedure

This material was prepared in analogy to example 8 step C) from piperidine-4-carboxylic acid (4-isopropyl-phenyl)-amide (0.123 g), 3-cyclopropylpropionic acid (0.057 g) as white solid (0.124 g). MS (ESI): 343.17 (MH+).

Sources & evidence

ORD record
ord-160c0e0eae694a9eaf2004b89b80e8f6
Source dataset
uspto-grants-2012_09
Patent number
US08258158B2

Reaction notes

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