HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethoxy)aniline → 4-Fluoro-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid (4-trifluoromethoxy-phenyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethoxy)aniline | HCID 600848 | — |
| Reactant | 4-Fluoro-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid | HCID 69810320 | — |
| Product | 4-Fluoro-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid (4-trifluoromethoxy-phenyl)-amide | HCID 51001068 | 32.7% |
Reaction Steps
This material was made in analogy to example 1 from 4-fluoro-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid (0.2 g) and 4-trifluoromethoxy-aniline (0.118 g) to give the desired 4-fluoro-1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid (4-trifluoromethoxy-phenyl)-amide (0.1 g) as a white solid. MS (ESI): 461.2 MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258158B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-b71a189c67504816b4647b3e3074a4be |
| Source note | uspto-grants-2012_09 |