Boron tribromide → HCID 51001654, compound

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Reaction Steps

1-(Toluene-4-sulfonyl)-piperidine-4-carboxylic acid [4-((R)-3-methoxy-1-trifluoromethyl-propoxy)-phenyl]-amide (0.105 g), product of example 59), in methylene chloride (2 ml) was treated at RT and under an argon atmosphere with BBr3 (0.5 molar, 1 ml) for 2 h. The mixture was then partitioned between diethyl ether and aqueous 1N HCL, the layers were separated, the organic layer was dried over sodium sulphate, and evaporated off to give the desired 1-(toluene-4-sulfonyl)-piperidine-4-carboxylic acid [4-((R)-3-hydroxy-1-trifluoromethyl-propoxy)-phenyl]-amide (0.073 g) as light brown crystalline solid. MS (ESI): 501.2 (MH+).

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