4-(Trifluoromethoxy)aniline → HCID 51001732, compound

HRID 2381189Notes

Reaction equation

HRID 2381189 reaction equation
[F:1][C:2]1([C:21]([OH:23])=O)[CH2:7][CH2:6][N:5]([S:8]([C:11]2[C:12]([C:17]([F:20])([F:19])[F:18])=[N:13][N:14]([CH3:16])[CH:15]=2)(=[O:10])=[O:9])[CH2:4][CH2:3]1.[F:24][C:25]([F:35])([F:34])[O:26][C:27]1[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=1>>[F:24][C:25]([F:34])([F:35])[O:26][C:27]1[CH:28]=[CH:29][C:30]([NH:31][C:21]([C:2]2([F:1])[CH2:3][CH2:4][N:5]([S:8]([C:11]3[C:12]([C:17]([F:18])([F:19])[F:20])=[N:13][N:14]([CH3:16])[CH:15]=3)(=[O:9])=[O:10])[CH2:6][CH2:7]2)=[O:23])=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 6008484-(Trifluoromethoxy)anilineHCID 69811926HCID 69811926, compound

Product 1

HCID 51001732HCID 51001732, compoundYield 15.8%

Procedure

This material was made in analogy to example 1 from 4-fluoro-1-(1-methyl-3-trifluoromethyl-1H-pyrazole-4-sulfonyl)-piperidine-4-carboxylic acid (0.176 g) and 4-trifluoromethoxy-aniline (0.087 g) to give the desired 4-fluoro-1-(1-methyl-3-trifluoromethyl-1H-pyrazole-4-sulfonyl)-piperidine-4-carboxylic acid (4-trifluoromethoxy-phenyl)-amide (0.04 g) as a white solid. MS (ESI): 519.28 (MH+).

Sources & evidence

ORD record
ord-2587259bcd8a438f995a04f6709683ce
Source dataset
uspto-grants-2012_09
Patent number
US08258158B2

Reaction notes

Loading…