HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 4-Benzyloxy-2-iodo-5-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-Benzyloxy-2-iodo-5-methoxybenzaldehyde | HCID 12773087 | — |
| Reactant | Sodium Chlorite | HCID 23668197 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Benzyloxy-2-iodo-5-methoxybenzoic acid | HCID 58345581 | — |
Reaction Steps
A mixture of 4-benzyloxy-2-iodo-5-methoxybenzaldehyde (reference example 1-1) (20 g), dimethylsulfoxide (19 mL), concentrated sulfuric acid (3 mL), water (30 mL) and acetonitrile (181 mL) was added a mixture of sodium chlorite (9.8 g) and water (30 mL). After stirring at room temperature for 30 minutes, water was added to the mixture. Insoluble materials were collected by filtration to give the title compound (20.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258162B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-b43f4da8e86247cfa1d44d64e56f4b32 |
| Source note | uspto-grants-2012_09 |