Dimethyl Sulfoxide → HCID 67110067, compound

Participants

Reaction Steps

A mixture of (5-benzyloxy-2-bromo-4-methoxyphenyl)-cyclohexylmethanol (Reference example 9-2) (580 mg), triethylamine (0.797 mL) and dimethylsulfoxide (21 mL) was added pyridine sulfur trioxide complex (684 mg) under ice-bath cooling. After stirring at room temperature for an hour, water and ethyl acetate were added to the mixture. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 0%-50% ethyl acetate/hexane, gradient elution) to give the title compound (348 mg).

Provenance & Evidence