Dimethyl dicarbonate → HCID 67110182, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-benzyloxy-2-cyano-4-methoxybenzoic acid (reference example 5-3) (502 mg), 2-fluorophenylboronic acid (297 mg), tetrakis(triphenylphosphine)palladium(0) (205 mg), dimethylpyrocarbonate (2 mL) and 1,4-dioxane (10 mL) was stirred at 80° C. under an argon atmosphere for 1.25 hours. Ethyl acetate and Florisil (registered mark) (2 g) were added. After stirring for 15 minutes, the mixture was passed through a layer of Celite (registered mark). The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 5%-30% ethyl acetate/hexane, gradient elution) to give the title compound (338 mg).

Provenance & Evidence