HCID 58345572, compound → HCID 58345590, compound

Participants

Reaction Steps

A mixture of isopropyl 4-benzyloxy-2-(2-bromobenzoyl)-5-methoxybenzoate (reference example 11-9) (600 mg), copper(I) cyanide (445 mg), tris(dibenzylideneacetone)dipalladium (114 mg), tetraethylammonium cyanide (194 mg), 1,1′bis(diphenylphosphino)ferrocene (206 mg) and 1,4-dioxane (73 mL) was stirred under reflux overnight. The mixture was passed through a layer of Celite (registered mark). The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 5%-30% ethyl acetate/hexane, gradient elution) to give the title compound (412 mg).

Provenance & Evidence