Hydrochloric Acid → HCID 58345621, compound

Participants

Reaction Steps

To a mixture of ethyl 2-benzoyl-4-benzyloxy-5-methoxy-benzoate (reference example 11-1) (848 mg) and dichloromethane (30 mL) was added titanium tetrachloride (0.31 mL) under room temperature. After stirring for 30 minutes, 2 mol/L hydrochloric acid and ethyl acetate were added to the mixture. The separated organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 10%-100% ethyl acetate/hexane, gradient elution) to give the title compound (550 mg).

Provenance & Evidence