Water → HCID 58345598, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-fluorobenzoyl)-4,5-dihydroxy-3-nitrobenzonitrile (compound 1-29) (70 mg), ethyl chloro-carbonate (30 mg) and N,N-dimethylforamide (1 mL) was stirred at 50° C. for 3 hours. Water and ethyl acetate were added to the mixture. The organic layer was washed with water, and dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 50-100% ethyl acetate/hexane, gradient elution) to give the title compound (60 mg). The structural formula was illustrated in table 10.

Provenance & Evidence