Tetrahydrofuran → HCID 53629726, compound

Participants

Reaction Steps

To a mixture of 2-(2-fluorobenzoyl)-4,5-dihydroxy-3-nitrobenzonitrile (compound 1-29) (70 mg) and tetrahydrofuran (2.0 mL) were added ethyl chlorocarbonate (70 μl) and triethylamine (110 μl) under ice-bath cooling. After stirring for 30 minutes, the mixture was stirred at room temperature for 2 days. The mixture was diluted with ethyl acetate, and washed with 1 mol/L hydrochloric acid and brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 0%-30% ethyl acetate/hexane, gradient elution) to give the title compound (103 mg). The structural formula was illustrated in table 10.

Provenance & Evidence