2-methyl-1-(3-nitro-1H-pyrazol-1-yl)propan-2-ol → 1-(3-amino-1H-pyrazol-1-yl)-2-methylpropan-2-ol

Participants

Reaction Steps

In a Parr shaker bottle was placed 2-methyl-1-(3-nitro-pyrazol-1-yl)-propan-2-ol (100 mg, 0.54 mmol), 10% palladium on activated carbon (10 mg) and ethanol (5 mL). The bottle was then placed on the Parr shaker under hydrogen (50 psi) for 1 h. The reaction was then filtered through a pad of diatomaceous earth, washed with ethanol, and concentrated in vacuo to afford 1-(3-amino-pyrazol-1-yl)-2-methyl-propan-2-ol (78 mg, 94%), which was taken on to the next step without characterization.

Provenance & Evidence