反应详情

A solution of 1-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-3-nitro-1H-pyrazole (348.4 mg, 1.53 mmol) in methanol (10 mL, 0.15M) in a high pressure reaction bottle was treated with 10% palladium on activated carbon (19.5 mg). The mixture was placed on a Parr shaker and exposed to hydrogen (40 psi) overnight. After this time, the reaction mixture was filtered through a pad of diatomaceous earth and rinsed with ethanol. The filtrate was concentrated in vacuo to afford 1-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine (237.4 mg, 1.20 mmol) as a viscous, yellow oil. The material was used without further purification.

1. filtrationAfter this time, the reaction mixture was filtered through a pad of diatomaceous earth
2. washrinsed with ethanol
3. concentrationThe filtrate was concentrated in vacuo